Michel Versluis, UTwente

Title: On the stability of monodisperse phospholipid-coated microbubbles formed by flow-focusing at high production rates
Session: Monday 5 October, 17:15

Abstract

Monodisperse microdroplets and microbubbles are important for a range of industrial and medical applications. For, example, monodisperse ultrasound contrast agents dramatically increase the sensitivity and efficiency in ultrasound imaging and therapy. Bubbles of a size of 1 to 10 μm can be produced at a rate of 1 million bubbles per second in a microfluidic flow-focusing device, but questions remain as to the interfacial chemistry, such as the formation and development of the stabilizing phospholipid coating over time. Here we demonstrate the synthesis of clinically relevant monodisperse bubbles with excellent control over size, resonance and coating characteristics. All bubbles were found to dissolve to a stable final radius, independent of the nozzle size and shear rate, indicating that the monolayer self-assembles prior to leaving the nozzle and compresses uniformly to mechanical equilibrium. These findings show excellent control over microbubble stability of interest for medical and food-industry applications.

 

 

 

Bio

Michel Versluis graduated in Physics in 1988 at the University of Nijmegen, the Netherlands, with a special interest in Molecular Physics and Astrophysics. Later, he specialized in the application of laser-induced fluorescence imaging for flame diagnostics resulting in a successful defense of his PhD thesis in 1992. Michel Versluis is now a professor at the University of Twente, the Netherlands, in the Physics of Fluids group working in the field of physical acoustics and medical acoustics. He specializes in nanomedicine applications using bubbles, drops and nanoparticles as a tool for medical diagnosis and therapy.

 

 

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