Robbert Jan Kok, University Utrecht

Title: Polymeric nanoparticles for cell-specific targeting of Mtor inhibitors to the kidney
Session: Tuesday 6 October, 11:45


We have developed polymeric nanoparticles for delivery of MTOR signaling inhibitors to the kidney. The mTOR pathway is an important signaling cascade in inflammatory and fibrotic disease, and mTOR-targeted nanomedicines can provide effective drug levels in kidney cell types like podocytes, tubular cells and glomerular endothelial cells.
PEG-PLGA polymeric nanoparticles were prepared by O/W emulsification and loaded with hydrophobic mTOR inhibitors while target-cell directed antibodies were covalently conjugated to the hydrophilic surface of the polymeric nanoparticles. Receptor-mediated endocytosis of such nanoparticles facilitates the intracellular delivery of the mTOR inhibitor in specific kidney cell types that express inflammation –associated adhesion molecules. Cell-specific targeting of signaling inhibitors allows a dual restriction in the targeted action of nanomedicines, both by specific cellular recognition and molecular targeting of specific signaling pathways.



 to be announced


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