Chrit Moonen, UMC Utrecht

Title: Ultrasound triggered, Image Guided, Drug delivery
Session: Monday 5 October, 15:45

Abstract

The goal of image guided drug delivery (IGDD) is to increase the therapeutic index of pharmacological treatments while decreasing adverse effects of drugs by better controlling the pharmacokinetics (PK) and pharmacodynamics (PD) of therapy. Here, special attention is paid to the field of ultrasound triggered IGDD.

High frequency sound waves can lead to local tissue heating, cavitation, and radiation force in tissue, which can be used for 1) local drug release from nanocarriers circulating in the blood, 2) increased extravasation and crossing of the Blood-Brain-Barrier, 3) increased cellular uptake, and 4) enhanced diffusivity of drugs. Nanocarriers sensitive to mechanical forces, and/or sensitive to temperature can be used to release the content of the nanocarriers locally. Molecular imaging methods based on MRI, optical and ultrasound, are used for guidance of actions to release drugs and/or permeabilize membranes, and for evaluation of biodistribution and PK/PD.

 

 

Bio

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